Current Build

Переводит команда Health Samurai . Приглашаем поучаствовать в русификации стандарта FHIR: GitHub , Email.

Biomedical Research and Regulation Work GroupMaturity Level: 0 Trial Use Compartments: Not linked to any defined compartments

Подробное описание элементов ресурса SubstanceNucleicAcid.

SubstanceNucleicAcid
Element IdSubstanceNucleicAcid
Definition

Nucleic acids are defined by three distinct elements: the base, sugar and linkage. Individual substance/moiety IDs will be created for each of these elements. The nucleotide sequence will be always entered in the 5’-3’ direction.

Control0..*
TypeDomainResource
Summarytrue
SubstanceNucleicAcid.sequenceType
Element IdSubstanceNucleicAcid.sequenceType
Definition

The type of the sequence shall be specified based on a controlled vocabulary.

Control0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.numberOfSubunits
Element IdSubstanceNucleicAcid.numberOfSubunits
Definition

The number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit.

Control0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.areaOfHybridisation
Element IdSubstanceNucleicAcid.areaOfHybridisation
Definition

The area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.oligoNucleotideType
Element IdSubstanceNucleicAcid.oligoNucleotideType
Definition

(TBC).

Control0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit
Element IdSubstanceNucleicAcid.subunit
Definition

Subunits are listed in order of decreasing length; sequences of the same length will be ordered by molecular weight; subunits that have identical sequences will be repeated multiple times.

Control0..*
Summarytrue
SubstanceNucleicAcid.subunit.subunit
Element IdSubstanceNucleicAcid.subunit.subunit
Definition

Index of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts.

Control0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.subunit.sequence
Element IdSubstanceNucleicAcid.subunit.sequence
Definition

Actual nucleotide sequence notation from 5' to 3' end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.length
Element IdSubstanceNucleicAcid.subunit.length
Definition

The length of the sequence shall be captured.

Control0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.subunit.sequenceAttachment
Element IdSubstanceNucleicAcid.subunit.sequenceAttachment
Definition

(TBC).

Control0..1
TypeAttachment
Summarytrue
SubstanceNucleicAcid.subunit.fivePrime
Element IdSubstanceNucleicAcid.subunit.fivePrime
Definition

The nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant.

Control0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit.threePrime
Element IdSubstanceNucleicAcid.subunit.threePrime
Definition

The nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant.

Control0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit.linkage
Element IdSubstanceNucleicAcid.subunit.linkage
Definition

The linkages between sugar residues will also be captured.

Control0..*
Summarytrue
SubstanceNucleicAcid.subunit.linkage.connectivity
Element IdSubstanceNucleicAcid.subunit.linkage.connectivity
Definition

The entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.linkage.identifier
Element IdSubstanceNucleicAcid.subunit.linkage.identifier
Definition

Each linkage will be registered as a fragment and have an ID.

NoteThis is a business identifer, not a resource identifier (see discussion)
Control0..1
TypeIdentifier
Summarytrue
SubstanceNucleicAcid.subunit.linkage.name
Element IdSubstanceNucleicAcid.subunit.linkage.name
Definition

Each linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.linkage.residueSite
Element IdSubstanceNucleicAcid.subunit.linkage.residueSite
Definition

Residues shall be captured as described in 5.3.6.8.3.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.sugar
Element IdSubstanceNucleicAcid.subunit.sugar
Definition

5.3.6.8.1 Sugar ID (Mandatory).

Control0..*
Summarytrue
SubstanceNucleicAcid.subunit.sugar.identifier
Element IdSubstanceNucleicAcid.subunit.sugar.identifier
Definition

The Substance ID of the sugar or sugar-like component that make up the nucleotide.

NoteThis is a business identifer, not a resource identifier (see discussion)
Control0..1
TypeIdentifier
Summarytrue
SubstanceNucleicAcid.subunit.sugar.name
Element IdSubstanceNucleicAcid.subunit.sugar.name
Definition

The name of the sugar or sugar-like component that make up the nucleotide.

Control0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.sugar.residueSite
Element IdSubstanceNucleicAcid.subunit.sugar.residueSite
Definition

The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above.

Control0..1
Typestring
Summarytrue