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Substancespecification.profile.json

Biomedical Research and Regulation Work GroupMaturity Level: N/ABallot Status: InformativeCompartments: Not linked to any defined compartments

Raw JSON (каноническая форма + also see JSON Format Specification)

StructureDefinition for substancespecification

{
  "resourceType" : "StructureDefinition",
  "id" : "SubstanceSpecification",
  "meta" : {
    "lastUpdated" : "2019-05-17T12:34:53.932+00:00"
  },
  "text" : {
    "status" : "generated",
    "div" : "<div>!-- Snipped for Brevity --></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode" : "trial-use"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger" : 0
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-security-category",
    "valueCode" : "anonymous"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode" : "brr"
  }],
  "url" : "http://hl7.org/fhir/StructureDefinition/SubstanceSpecification",
  "version" : "3.6.0",
  "name" : "SubstanceSpecification",
  "status" : "draft",
  "date" : "2019-05-17T12:34:53+00:00",
  "publisher" : "Health Level Seven International (Biomedical Research and Regulation)",
  "contact" : [{
    "telecom" : [{
      "system" : "url",
      "value" : "http://hl7.org/fhir"
    }]
  },
  {
    "telecom" : [{
      "system" : "url",
      "value" : "http://www.hl7.org/Special/committees/rcrim/index.cfm"
    }]
  }],
  "description" : "The detailed description of a substance, typically at a level beyond what is used for prescribing.",
  "fhirVersion" : "3.6.0",
  "mapping" : [{
    "identity" : "rim",
    "uri" : "http://hl7.org/v3",
    "name" : "RIM Mapping"
  }],
  "kind" : "resource",
  "abstract" : false,
  "type" : "SubstanceSpecification",
  "baseDefinition" : "http://hl7.org/fhir/StructureDefinition/DomainResource",
  "derivation" : "specialization",
  "snapshot" : {
    "element" : [{
      "id" : "SubstanceSpecification",
      "path" : "SubstanceSpecification",
      "short" : "The detailed description of a substance, typically at a level beyond what is used for prescribing",
      "definition" : "The detailed description of a substance, typically at a level beyond what is used for prescribing.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification",
        "min" : 0,
        "max" : "*"
      },
      "constraint" : [{
        "key" : "dom-2",
        "severity" : "error",
        "human" : "Если ресурс встроен в другой ресурс, он НЕ ДОЛЖЕН содержать описательной части",
        "expression" : "contained.contained.empty()",
        "xpath" : "not(parent::f:contained and f:contained)",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-4",
        "severity" : "error",
        "human" : "Если ресурс встроен в другой ресурс, он НЕ ДОЛЖЕН иметь meta.versionId или meta.lastUpdated",
        "expression" : "contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-3",
        "severity" : "error",
        "human" : "Если ресурс встроен в другой ресурс, где-то в родительском ресурсе на него ДОЛЖНА БЫТЬ дана ссылка or SHALL refer to the containing resource",
        "expression" : "contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()",
        "xpath" : "not(exists(for $contained in f:contained return $contained[not(parent::*/descendant::f:reference/@value=concat('#', $contained/*/id/@value) or descendant::f:reference[@value='#'])]))",
        "source" : "DomainResource"
      },
      {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice",
          "valueBoolean" : true
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation",
          "valueMarkdown" : "When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time."
        }],
        "key" : "dom-6",
        "severity" : "warning",
        "human" : "A resource should have narrative for robust management",
        "expression" : "text.div.exists()",
        "xpath" : "exists(f:text/h:div)",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-5",
        "severity" : "error",
        "human" : "If a resource is contained in another resource, it SHALL NOT have a security label",
        "expression" : "contained.meta.security.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:security))",
        "source" : "DomainResource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Entity. Role, or Act"
      }]
    },
    {
      "id" : "SubstanceSpecification.id",
      "path" : "SubstanceSpecification.id",
      "short" : "Logical id of this artifact",
      "definition" : "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
      "comment" : "The only time that a resource does not have an id is when it is being submitted to the server using a create operation.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "id"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.meta",
      "path" : "SubstanceSpecification.meta",
      "short" : "Метаданные ресурса",
      "definition" : "Метаданные ресурса. Это такая информация, которая поддерживается инфраструктурой. Изменения этой информации не всегда можно ассоциировать с версионными изменениями ресурса.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.meta",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Meta"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.implicitRules",
      "path" : "SubstanceSpecification.implicitRules",
      "short" : "Свод правил, в соответствии с которыми создавалось это содержимое",
      "definition" : "Ссылка на свод правил, которым следовали при создании этого ресурса и которые необходимо понимать при обработке этого содержимого. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
      "comment" : "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.implicitRules",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "uri"
      }],
      "isModifier" : true,
      "isModifierReason" : "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation",
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.language",
      "path" : "SubstanceSpecification.language",
      "short" : "Язык содержимого ресурса",
      "definition" : "Основной язык, на котором написан ресурс.",
      "comment" : "Язык указывается для поддержки предварительной обработки текстов и доступности для понимания (например при преобразовании текста в речь используется языковой тег). HTML-тег language в описательной части применяется к этой описательной части. Языковой тег ресурса может использоваться для указания языков других представлений, генерируемых из данных ресурса\n\nНе все содержание ресурса должно быть на указанном основном языке. Resource.language нельзя автоматически принимать за язык описательной части. Если язык указан, его также следует указать в элементе div в HTML (информацию о связи между xml:lang и HTML-атрибутом lang см. в правилах HTML5).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.language",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "code"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet",
          "valueCanonical" : "http://hl7.org/fhir/ValueSet/all-languages"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "Language"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-isCommonBinding",
          "valueBoolean" : true
        }],
        "strength" : "preferred",
        "description" : "Естественный язык.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/languages"
      }
    },
    {
      "id" : "SubstanceSpecification.text",
      "path" : "SubstanceSpecification.text",
      "short" : "Краткое текстовое изложение ресурса для интерпретации человеком",
      "definition" : "Человекочитаемая описательная часть, содержащая краткое изложение ресурса, которая может использоваться для представления содержимого ресурса человеку. От описательной части не требуется кодировать все структурированные данные, но она должна содержать достаточно сведений, чтобы простое её прочтение человеком было \"клинически безопасным\". Определения ресурсов могут описывать, какое содержимое должно быть представлено в описательной части для обеспечения клинической безопасной.",
      "comment" : "Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded information is added later.",
      "alias" : ["narrative",
      "html",
      "xhtml",
      "display"],
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "DomainResource.text",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Narrative"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Act.text?"
      }]
    },
    {
      "id" : "SubstanceSpecification.contained",
      "path" : "SubstanceSpecification.contained",
      "short" : "Вложенные, встроенные инлайн ресурсы",
      "definition" : "Эти ресурсы не обладают независимым существованием вне ресурса, который их содержит - их нельзя идентифицировать независимо, и они не могут иметь своей собственной независимой транзакционной области действия.",
      "comment" : "Этого не следует делать, когда содержимое может быть идентифицировано должным образом, поскольку, потеряв идентификацию, будет чрезвычайно сложно (и контекстно-зависимо) снова восстановить её. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels.",
      "alias" : ["inline resources",
      "anonymous resources",
      "contained resources"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.contained",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Resource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.extension",
      "path" : "SubstanceSpecification.extension",
      "short" : "Дополнительное содержимое, определенное реализаторами",
      "definition" : "Может использоваться для представления дополнительной информации, не являющейся частью базового определения ресурса. Чтобы сделать использование расширений надежным и управляемым, существует строгий набор управления применительно к определению и использованию расширений. Хотя каждому реализатору разрешается определять расширения, имеется набор требований, которые должны выполняться в рамках определения расширения.",
      "comment" : "Не должно быть никаких предрассудков по использованию расширений любыми приложениями, проектами или стандартами - вне зависимости от учреждения или юрисдикции, которые используют или задают расширение. Именно использование расширений позволяет спецификации FHIR сохранять простоту для всех.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.modifierExtension",
      "path" : "SubstanceSpecification.modifierExtension",
      "short" : "Расширения, которые нельзя игнорировать",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the resource, and that modifies the understanding of the element that contains it. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "Не должно быть никаких предрассудков по использованию расширений любыми приложениями, проектами или стандартами - вне зависимости от учреждения или юрисдикции, которые используют или задают расширение. Именно использование расширений позволяет спецификации FHIR сохранять простоту для всех.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them",
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.identifier",
      "path" : "SubstanceSpecification.identifier",
      "short" : "Identifier by which this substance is known",
      "definition" : "Identifier by which this substance is known.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.identifier",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Identifier"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.type",
      "path" : "SubstanceSpecification.type",
      "short" : "High level categorization, e.g. polymer or nucleic acid",
      "definition" : "High level categorization, e.g. polymer or nucleic acid.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.type",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.status",
      "path" : "SubstanceSpecification.status",
      "short" : "Status of substance within the catalogue e.g. approved",
      "definition" : "Status of substance within the catalogue e.g. approved.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.status",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.domain",
      "path" : "SubstanceSpecification.domain",
      "short" : "If the substance applies to only human or veterinary use",
      "definition" : "If the substance applies to only human or veterinary use.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.domain",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.description",
      "path" : "SubstanceSpecification.description",
      "short" : "Textual description of the substance",
      "definition" : "Textual description of the substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.description",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.source",
      "path" : "SubstanceSpecification.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.source",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.comment",
      "path" : "SubstanceSpecification.comment",
      "short" : "Textual comment about this record of a substance",
      "definition" : "Textual comment about this record of a substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.comment",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety",
      "path" : "SubstanceSpecification.moiety",
      "short" : "Moiety, for structural modifications",
      "definition" : "Moiety, for structural modifications.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.moiety",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.id",
      "path" : "SubstanceSpecification.moiety.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.moiety.extension",
      "path" : "SubstanceSpecification.moiety.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.moiety.modifierExtension",
      "path" : "SubstanceSpecification.moiety.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.moiety.role",
      "path" : "SubstanceSpecification.moiety.role",
      "short" : "Role that the moiety is playing",
      "definition" : "Role that the moiety is playing.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.role",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.identifier",
      "path" : "SubstanceSpecification.moiety.identifier",
      "short" : "Identifier by which this moiety substance is known",
      "definition" : "Identifier by which this moiety substance is known.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.identifier",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Identifier"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.name",
      "path" : "SubstanceSpecification.moiety.name",
      "short" : "Textual name for this moiety substance",
      "definition" : "Textual name for this moiety substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.name",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.stereochemistry",
      "path" : "SubstanceSpecification.moiety.stereochemistry",
      "short" : "Stereochemistry type",
      "definition" : "Stereochemistry type.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.stereochemistry",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.opticalActivity",
      "path" : "SubstanceSpecification.moiety.opticalActivity",
      "short" : "Optical activity type",
      "definition" : "Optical activity type.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.opticalActivity",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.molecularFormula",
      "path" : "SubstanceSpecification.moiety.molecularFormula",
      "short" : "Molecular formula",
      "definition" : "Molecular formula.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.molecularFormula",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.amount[x]",
      "path" : "SubstanceSpecification.moiety.amount[x]",
      "short" : "Quantitative value for this moiety",
      "definition" : "Quantitative value for this moiety.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.moiety.amount[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property",
      "path" : "SubstanceSpecification.property",
      "short" : "General specifications for this substance, including how it is related to other substances",
      "definition" : "General specifications for this substance, including how it is related to other substances.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.property",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.id",
      "path" : "SubstanceSpecification.property.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.property.extension",
      "path" : "SubstanceSpecification.property.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.property.modifierExtension",
      "path" : "SubstanceSpecification.property.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.property.category",
      "path" : "SubstanceSpecification.property.category",
      "short" : "A category for this property, e.g. Physical, Chemical, Enzymatic",
      "definition" : "A category for this property, e.g. Physical, Chemical, Enzymatic.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.property.category",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.code",
      "path" : "SubstanceSpecification.property.code",
      "short" : "Property type e.g. viscosity, pH, isoelectric point",
      "definition" : "Property type e.g. viscosity, pH, isoelectric point.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.property.code",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.parameters",
      "path" : "SubstanceSpecification.property.parameters",
      "short" : "Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)",
      "definition" : "Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.property.parameters",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.definingSubstance[x]",
      "path" : "SubstanceSpecification.property.definingSubstance[x]",
      "short" : "A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)",
      "definition" : "A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.property.definingSubstance[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSpecification",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      },
      {
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.amount[x]",
      "path" : "SubstanceSpecification.property.amount[x]",
      "short" : "Quantitative value for this property",
      "definition" : "Quantitative value for this property.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.property.amount[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.referenceInformation",
      "path" : "SubstanceSpecification.referenceInformation",
      "short" : "General information detailing this substance",
      "definition" : "General information detailing this substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.referenceInformation",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceReferenceInformation"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure",
      "path" : "SubstanceSpecification.structure",
      "short" : "Structural information",
      "definition" : "Structural information.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.id",
      "path" : "SubstanceSpecification.structure.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.extension",
      "path" : "SubstanceSpecification.structure.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.modifierExtension",
      "path" : "SubstanceSpecification.structure.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.stereochemistry",
      "path" : "SubstanceSpecification.structure.stereochemistry",
      "short" : "Stereochemistry type",
      "definition" : "Stereochemistry type.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.stereochemistry",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.opticalActivity",
      "path" : "SubstanceSpecification.structure.opticalActivity",
      "short" : "Optical activity type",
      "definition" : "Optical activity type.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.opticalActivity",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularFormula",
      "path" : "SubstanceSpecification.structure.molecularFormula",
      "short" : "Molecular formula",
      "definition" : "Molecular formula.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.molecularFormula",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularFormulaByMoiety",
      "path" : "SubstanceSpecification.structure.molecularFormulaByMoiety",
      "short" : "Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot",
      "definition" : "Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.molecularFormulaByMoiety",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope",
      "path" : "SubstanceSpecification.structure.isotope",
      "short" : "Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio",
      "definition" : "Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.id",
      "path" : "SubstanceSpecification.structure.isotope.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.extension",
      "path" : "SubstanceSpecification.structure.isotope.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.modifierExtension",
      "path" : "SubstanceSpecification.structure.isotope.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.identifier",
      "path" : "SubstanceSpecification.structure.isotope.identifier",
      "short" : "Substance identifier for each non-natural or radioisotope",
      "definition" : "Substance identifier for each non-natural or radioisotope.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.identifier",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Identifier"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.name",
      "path" : "SubstanceSpecification.structure.isotope.name",
      "short" : "Substance name for each non-natural or radioisotope",
      "definition" : "Substance name for each non-natural or radioisotope.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.name",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.substitution",
      "path" : "SubstanceSpecification.structure.isotope.substitution",
      "short" : "The type of isotopic substitution present in a single substance",
      "definition" : "The type of isotopic substitution present in a single substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.substitution",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.halfLife",
      "path" : "SubstanceSpecification.structure.isotope.halfLife",
      "short" : "Half life - for a non-natural nuclide",
      "definition" : "Half life - for a non-natural nuclide.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.halfLife",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Quantity"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.molecularWeight",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.id",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.extension",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.modifierExtension",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.method",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.method",
      "short" : "The method by which the molecular weight was determined",
      "definition" : "The method by which the molecular weight was determined.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.molecularWeight.method",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.type",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.type",
      "short" : "Type of molecular weight such as exact, average (also known as. number average), weight average",
      "definition" : "Type of molecular weight such as exact, average (also known as. number average), weight average.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.molecularWeight.type",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.amount",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.amount",
      "short" : "Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field",
      "definition" : "Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.isotope.molecularWeight.amount",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Quantity"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularWeight",
      "path" : "SubstanceSpecification.structure.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.molecularWeight",
        "min" : 0,
        "max" : "1"
      },
      "contentReference" : "#SubstanceSpecification.structure.isotope.molecularWeight",
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.source",
      "path" : "SubstanceSpecification.structure.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.structure.source",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation",
      "path" : "SubstanceSpecification.structure.representation",
      "short" : "Molecular structural representation",
      "definition" : "Molecular structural representation.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.structure.representation",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.id",
      "path" : "SubstanceSpecification.structure.representation.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.representation.extension",
      "path" : "SubstanceSpecification.structure.representation.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.representation.modifierExtension",
      "path" : "SubstanceSpecification.structure.representation.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.structure.representation.type",
      "path" : "SubstanceSpecification.structure.representation.type",
      "short" : "The type of structure (e.g. Full, Partial, Representative)",
      "definition" : "The type of structure (e.g. Full, Partial, Representative).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.representation.type",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.representation",
      "path" : "SubstanceSpecification.structure.representation.representation",
      "short" : "The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX",
      "definition" : "The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.representation.representation",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.attachment",
      "path" : "SubstanceSpecification.structure.representation.attachment",
      "short" : "An attached file with the structural representation",
      "definition" : "An attached file with the structural representation.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.structure.representation.attachment",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Attachment"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code",
      "path" : "SubstanceSpecification.code",
      "short" : "Codes associated with the substance",
      "definition" : "Codes associated with the substance.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.code",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.id",
      "path" : "SubstanceSpecification.code.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.code.extension",
      "path" : "SubstanceSpecification.code.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.code.modifierExtension",
      "path" : "SubstanceSpecification.code.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.code.code",
      "path" : "SubstanceSpecification.code.code",
      "short" : "The specific code",
      "definition" : "The specific code.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.code.code",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.status",
      "path" : "SubstanceSpecification.code.status",
      "short" : "Status of the code assignment",
      "definition" : "Status of the code assignment.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.code.status",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.statusDate",
      "path" : "SubstanceSpecification.code.statusDate",
      "short" : "The date at which the code status is changed as part of the terminology maintenance",
      "definition" : "The date at which the code status is changed as part of the terminology maintenance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.code.statusDate",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "dateTime"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.comment",
      "path" : "SubstanceSpecification.code.comment",
      "short" : "Any comment can be provided in this field, if necessary",
      "definition" : "Any comment can be provided in this field, if necessary.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.code.comment",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.source",
      "path" : "SubstanceSpecification.code.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.code.source",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name",
      "path" : "SubstanceSpecification.name",
      "short" : "Names applicable to this substance",
      "definition" : "Names applicable to this substance.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.id",
      "path" : "SubstanceSpecification.name.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.extension",
      "path" : "SubstanceSpecification.name.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.modifierExtension",
      "path" : "SubstanceSpecification.name.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.name",
      "path" : "SubstanceSpecification.name.name",
      "short" : "The actual name",
      "definition" : "The actual name.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.name",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.type",
      "path" : "SubstanceSpecification.name.type",
      "short" : "Name type",
      "definition" : "Name type.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.type",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.status",
      "path" : "SubstanceSpecification.name.status",
      "short" : "The status of the name",
      "definition" : "The status of the name.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.status",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.preferred",
      "path" : "SubstanceSpecification.name.preferred",
      "short" : "If this is the preferred name for this substance",
      "definition" : "If this is the preferred name for this substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.preferred",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "boolean"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.language",
      "path" : "SubstanceSpecification.name.language",
      "short" : "Language of the name",
      "definition" : "Language of the name.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.language",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.domain",
      "path" : "SubstanceSpecification.name.domain",
      "short" : "The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive",
      "definition" : "The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.domain",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.jurisdiction",
      "path" : "SubstanceSpecification.name.jurisdiction",
      "short" : "The jurisdiction where this name applies",
      "definition" : "The jurisdiction where this name applies.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.jurisdiction",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.synonym",
      "path" : "SubstanceSpecification.name.synonym",
      "short" : "A synonym of this name",
      "definition" : "A synonym of this name.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.synonym",
        "min" : 0,
        "max" : "*"
      },
      "contentReference" : "#SubstanceSpecification.name",
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.translation",
      "path" : "SubstanceSpecification.name.translation",
      "short" : "A translation for this name",
      "definition" : "A translation for this name.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.translation",
        "min" : 0,
        "max" : "*"
      },
      "contentReference" : "#SubstanceSpecification.name",
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official",
      "path" : "SubstanceSpecification.name.official",
      "short" : "Details of the official nature of this name",
      "definition" : "Details of the official nature of this name.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.official",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.id",
      "path" : "SubstanceSpecification.name.official.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.official.extension",
      "path" : "SubstanceSpecification.name.official.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.official.modifierExtension",
      "path" : "SubstanceSpecification.name.official.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.name.official.authority",
      "path" : "SubstanceSpecification.name.official.authority",
      "short" : "Which authority uses this official name",
      "definition" : "Which authority uses this official name.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.official.authority",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.status",
      "path" : "SubstanceSpecification.name.official.status",
      "short" : "The status of the official name",
      "definition" : "The status of the official name.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.official.status",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.date",
      "path" : "SubstanceSpecification.name.official.date",
      "short" : "Date of official name change",
      "definition" : "Date of official name change.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.name.official.date",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "dateTime"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.source",
      "path" : "SubstanceSpecification.name.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.name.source",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.molecularWeight",
      "path" : "SubstanceSpecification.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.molecularWeight",
        "min" : 0,
        "max" : "*"
      },
      "contentReference" : "#SubstanceSpecification.structure.isotope.molecularWeight",
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship",
      "path" : "SubstanceSpecification.relationship",
      "short" : "A link between this substance and another, with details of the relationship",
      "definition" : "A link between this substance and another, with details of the relationship.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.relationship",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.id",
      "path" : "SubstanceSpecification.relationship.id",
      "representation" : ["xmlAttr"],
      "short" : "xml:id (or equivalent in JSON)",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.relationship.extension",
      "path" : "SubstanceSpecification.relationship.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "SubstanceSpecification.relationship.modifierExtension",
      "path" : "SubstanceSpecification.relationship.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "SubstanceSpecification.relationship.substance[x]",
      "path" : "SubstanceSpecification.relationship.substance[x]",
      "short" : "A pointer to another substance, as a resource or just a representational code",
      "definition" : "A pointer to another substance, as a resource or just a representational code.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.substance[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSpecification"]
      },
      {
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.relationship",
      "path" : "SubstanceSpecification.relationship.relationship",
      "short" : "For example \"salt to parent\", \"active moiety\", \"starting material\"",
      "definition" : "For example \"salt to parent\", \"active moiety\", \"starting material\".",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.relationship",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.isDefining",
      "path" : "SubstanceSpecification.relationship.isDefining",
      "short" : "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships",
      "definition" : "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.isDefining",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "boolean"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amount[x]",
      "path" : "SubstanceSpecification.relationship.amount[x]",
      "short" : "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other",
      "definition" : "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.amount[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "Range"
      },
      {
        "code" : "Ratio"
      },
      {
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amountRatioLowLimit",
      "path" : "SubstanceSpecification.relationship.amountRatioLowLimit",
      "short" : "For use when the numeric",
      "definition" : "For use when the numeric.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.amountRatioLowLimit",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amountType",
      "path" : "SubstanceSpecification.relationship.amountType",
      "short" : "An operator for the amount, for example \"average\", \"approximately\", \"less than\"",
      "definition" : "An operator for the amount, for example \"average\", \"approximately\", \"less than\".",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.relationship.amountType",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.source",
      "path" : "SubstanceSpecification.relationship.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "SubstanceSpecification.relationship.source",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.nucleicAcid",
      "path" : "SubstanceSpecification.nucleicAcid",
      "short" : "Data items specific to nucleic acids",
      "definition" : "Data items specific to nucleic acids.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.nucleicAcid",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceNucleicAcid"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.polymer",
      "path" : "SubstanceSpecification.polymer",
      "short" : "Data items specific to polymers",
      "definition" : "Data items specific to polymers.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.polymer",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstancePolymer"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.protein",
      "path" : "SubstanceSpecification.protein",
      "short" : "Data items specific to proteins",
      "definition" : "Data items specific to proteins.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.protein",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceProtein"]
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.sourceMaterial",
      "path" : "SubstanceSpecification.sourceMaterial",
      "short" : "Material or taxonomic/anatomical source for the substance",
      "definition" : "Material or taxonomic/anatomical source for the substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "SubstanceSpecification.sourceMaterial",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSourceMaterial"]
      }],
      "isModifier" : false,
      "isSummary" : true
    }]
  },
  "differential" : {
    "element" : [{
      "id" : "SubstanceSpecification",
      "path" : "SubstanceSpecification",
      "short" : "The detailed description of a substance, typically at a level beyond what is used for prescribing",
      "definition" : "The detailed description of a substance, typically at a level beyond what is used for prescribing.",
      "min" : 0,
      "max" : "*"
    },
    {
      "id" : "SubstanceSpecification.identifier",
      "path" : "SubstanceSpecification.identifier",
      "short" : "Identifier by which this substance is known",
      "definition" : "Identifier by which this substance is known.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Identifier"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.type",
      "path" : "SubstanceSpecification.type",
      "short" : "High level categorization, e.g. polymer or nucleic acid",
      "definition" : "High level categorization, e.g. polymer or nucleic acid.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.status",
      "path" : "SubstanceSpecification.status",
      "short" : "Status of substance within the catalogue e.g. approved",
      "definition" : "Status of substance within the catalogue e.g. approved.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.domain",
      "path" : "SubstanceSpecification.domain",
      "short" : "If the substance applies to only human or veterinary use",
      "definition" : "If the substance applies to only human or veterinary use.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.description",
      "path" : "SubstanceSpecification.description",
      "short" : "Textual description of the substance",
      "definition" : "Textual description of the substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.source",
      "path" : "SubstanceSpecification.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.comment",
      "path" : "SubstanceSpecification.comment",
      "short" : "Textual comment about this record of a substance",
      "definition" : "Textual comment about this record of a substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety",
      "path" : "SubstanceSpecification.moiety",
      "short" : "Moiety, for structural modifications",
      "definition" : "Moiety, for structural modifications.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.role",
      "path" : "SubstanceSpecification.moiety.role",
      "short" : "Role that the moiety is playing",
      "definition" : "Role that the moiety is playing.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.identifier",
      "path" : "SubstanceSpecification.moiety.identifier",
      "short" : "Identifier by which this moiety substance is known",
      "definition" : "Identifier by which this moiety substance is known.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Identifier"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.name",
      "path" : "SubstanceSpecification.moiety.name",
      "short" : "Textual name for this moiety substance",
      "definition" : "Textual name for this moiety substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.stereochemistry",
      "path" : "SubstanceSpecification.moiety.stereochemistry",
      "short" : "Stereochemistry type",
      "definition" : "Stereochemistry type.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.opticalActivity",
      "path" : "SubstanceSpecification.moiety.opticalActivity",
      "short" : "Optical activity type",
      "definition" : "Optical activity type.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.molecularFormula",
      "path" : "SubstanceSpecification.moiety.molecularFormula",
      "short" : "Molecular formula",
      "definition" : "Molecular formula.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.moiety.amount[x]",
      "path" : "SubstanceSpecification.moiety.amount[x]",
      "short" : "Quantitative value for this moiety",
      "definition" : "Quantitative value for this moiety.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property",
      "path" : "SubstanceSpecification.property",
      "short" : "General specifications for this substance, including how it is related to other substances",
      "definition" : "General specifications for this substance, including how it is related to other substances.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.category",
      "path" : "SubstanceSpecification.property.category",
      "short" : "A category for this property, e.g. Physical, Chemical, Enzymatic",
      "definition" : "A category for this property, e.g. Physical, Chemical, Enzymatic.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.code",
      "path" : "SubstanceSpecification.property.code",
      "short" : "Property type e.g. viscosity, pH, isoelectric point",
      "definition" : "Property type e.g. viscosity, pH, isoelectric point.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.parameters",
      "path" : "SubstanceSpecification.property.parameters",
      "short" : "Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)",
      "definition" : "Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1).",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.definingSubstance[x]",
      "path" : "SubstanceSpecification.property.definingSubstance[x]",
      "short" : "A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)",
      "definition" : "A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol).",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSpecification",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      },
      {
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.property.amount[x]",
      "path" : "SubstanceSpecification.property.amount[x]",
      "short" : "Quantitative value for this property",
      "definition" : "Quantitative value for this property.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.referenceInformation",
      "path" : "SubstanceSpecification.referenceInformation",
      "short" : "General information detailing this substance",
      "definition" : "General information detailing this substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceReferenceInformation"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure",
      "path" : "SubstanceSpecification.structure",
      "short" : "Structural information",
      "definition" : "Structural information.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.stereochemistry",
      "path" : "SubstanceSpecification.structure.stereochemistry",
      "short" : "Stereochemistry type",
      "definition" : "Stereochemistry type.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.opticalActivity",
      "path" : "SubstanceSpecification.structure.opticalActivity",
      "short" : "Optical activity type",
      "definition" : "Optical activity type.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularFormula",
      "path" : "SubstanceSpecification.structure.molecularFormula",
      "short" : "Molecular formula",
      "definition" : "Molecular formula.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularFormulaByMoiety",
      "path" : "SubstanceSpecification.structure.molecularFormulaByMoiety",
      "short" : "Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot",
      "definition" : "Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope",
      "path" : "SubstanceSpecification.structure.isotope",
      "short" : "Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio",
      "definition" : "Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.identifier",
      "path" : "SubstanceSpecification.structure.isotope.identifier",
      "short" : "Substance identifier for each non-natural or radioisotope",
      "definition" : "Substance identifier for each non-natural or radioisotope.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Identifier"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.name",
      "path" : "SubstanceSpecification.structure.isotope.name",
      "short" : "Substance name for each non-natural or radioisotope",
      "definition" : "Substance name for each non-natural or radioisotope.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.substitution",
      "path" : "SubstanceSpecification.structure.isotope.substitution",
      "short" : "The type of isotopic substitution present in a single substance",
      "definition" : "The type of isotopic substitution present in a single substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.halfLife",
      "path" : "SubstanceSpecification.structure.isotope.halfLife",
      "short" : "Half life - for a non-natural nuclide",
      "definition" : "Half life - for a non-natural nuclide.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Quantity"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.method",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.method",
      "short" : "The method by which the molecular weight was determined",
      "definition" : "The method by which the molecular weight was determined.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.type",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.type",
      "short" : "Type of molecular weight such as exact, average (also known as. number average), weight average",
      "definition" : "Type of molecular weight such as exact, average (also known as. number average), weight average.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.isotope.molecularWeight.amount",
      "path" : "SubstanceSpecification.structure.isotope.molecularWeight.amount",
      "short" : "Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field",
      "definition" : "Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Quantity"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.molecularWeight",
      "path" : "SubstanceSpecification.structure.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "1",
      "contentReference" : "#SubstanceSpecification.structure.isotope.molecularWeight",
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.source",
      "path" : "SubstanceSpecification.structure.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation",
      "path" : "SubstanceSpecification.structure.representation",
      "short" : "Molecular structural representation",
      "definition" : "Molecular structural representation.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.type",
      "path" : "SubstanceSpecification.structure.representation.type",
      "short" : "The type of structure (e.g. Full, Partial, Representative)",
      "definition" : "The type of structure (e.g. Full, Partial, Representative).",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.representation",
      "path" : "SubstanceSpecification.structure.representation.representation",
      "short" : "The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX",
      "definition" : "The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.structure.representation.attachment",
      "path" : "SubstanceSpecification.structure.representation.attachment",
      "short" : "An attached file with the structural representation",
      "definition" : "An attached file with the structural representation.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Attachment"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code",
      "path" : "SubstanceSpecification.code",
      "short" : "Codes associated with the substance",
      "definition" : "Codes associated with the substance.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.code",
      "path" : "SubstanceSpecification.code.code",
      "short" : "The specific code",
      "definition" : "The specific code.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.status",
      "path" : "SubstanceSpecification.code.status",
      "short" : "Status of the code assignment",
      "definition" : "Status of the code assignment.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.statusDate",
      "path" : "SubstanceSpecification.code.statusDate",
      "short" : "The date at which the code status is changed as part of the terminology maintenance",
      "definition" : "The date at which the code status is changed as part of the terminology maintenance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "dateTime"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.comment",
      "path" : "SubstanceSpecification.code.comment",
      "short" : "Any comment can be provided in this field, if necessary",
      "definition" : "Any comment can be provided in this field, if necessary.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.code.source",
      "path" : "SubstanceSpecification.code.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name",
      "path" : "SubstanceSpecification.name",
      "short" : "Names applicable to this substance",
      "definition" : "Names applicable to this substance.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.name",
      "path" : "SubstanceSpecification.name.name",
      "short" : "The actual name",
      "definition" : "The actual name.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.type",
      "path" : "SubstanceSpecification.name.type",
      "short" : "Name type",
      "definition" : "Name type.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.status",
      "path" : "SubstanceSpecification.name.status",
      "short" : "The status of the name",
      "definition" : "The status of the name.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.preferred",
      "path" : "SubstanceSpecification.name.preferred",
      "short" : "If this is the preferred name for this substance",
      "definition" : "If this is the preferred name for this substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "boolean"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.language",
      "path" : "SubstanceSpecification.name.language",
      "short" : "Language of the name",
      "definition" : "Language of the name.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.domain",
      "path" : "SubstanceSpecification.name.domain",
      "short" : "The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive",
      "definition" : "The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.jurisdiction",
      "path" : "SubstanceSpecification.name.jurisdiction",
      "short" : "The jurisdiction where this name applies",
      "definition" : "The jurisdiction where this name applies.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.synonym",
      "path" : "SubstanceSpecification.name.synonym",
      "short" : "A synonym of this name",
      "definition" : "A synonym of this name.",
      "min" : 0,
      "max" : "*",
      "contentReference" : "#SubstanceSpecification.name",
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.translation",
      "path" : "SubstanceSpecification.name.translation",
      "short" : "A translation for this name",
      "definition" : "A translation for this name.",
      "min" : 0,
      "max" : "*",
      "contentReference" : "#SubstanceSpecification.name",
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official",
      "path" : "SubstanceSpecification.name.official",
      "short" : "Details of the official nature of this name",
      "definition" : "Details of the official nature of this name.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.authority",
      "path" : "SubstanceSpecification.name.official.authority",
      "short" : "Which authority uses this official name",
      "definition" : "Which authority uses this official name.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.status",
      "path" : "SubstanceSpecification.name.official.status",
      "short" : "The status of the official name",
      "definition" : "The status of the official name.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.official.date",
      "path" : "SubstanceSpecification.name.official.date",
      "short" : "Date of official name change",
      "definition" : "Date of official name change.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "dateTime"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.name.source",
      "path" : "SubstanceSpecification.name.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.molecularWeight",
      "path" : "SubstanceSpecification.molecularWeight",
      "short" : "The molecular weight or weight range (for proteins, polymers or nucleic acids)",
      "definition" : "The molecular weight or weight range (for proteins, polymers or nucleic acids).",
      "min" : 0,
      "max" : "*",
      "contentReference" : "#SubstanceSpecification.structure.isotope.molecularWeight",
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship",
      "path" : "SubstanceSpecification.relationship",
      "short" : "A link between this substance and another, with details of the relationship",
      "definition" : "A link between this substance and another, with details of the relationship.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.substance[x]",
      "path" : "SubstanceSpecification.relationship.substance[x]",
      "short" : "A pointer to another substance, as a resource or just a representational code",
      "definition" : "A pointer to another substance, as a resource or just a representational code.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSpecification"]
      },
      {
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.relationship",
      "path" : "SubstanceSpecification.relationship.relationship",
      "short" : "For example \"salt to parent\", \"active moiety\", \"starting material\"",
      "definition" : "For example \"salt to parent\", \"active moiety\", \"starting material\".",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.isDefining",
      "path" : "SubstanceSpecification.relationship.isDefining",
      "short" : "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships",
      "definition" : "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "boolean"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amount[x]",
      "path" : "SubstanceSpecification.relationship.amount[x]",
      "short" : "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other",
      "definition" : "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Quantity"
      },
      {
        "code" : "Range"
      },
      {
        "code" : "Ratio"
      },
      {
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amountRatioLowLimit",
      "path" : "SubstanceSpecification.relationship.amountRatioLowLimit",
      "short" : "For use when the numeric",
      "definition" : "For use when the numeric.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.amountType",
      "path" : "SubstanceSpecification.relationship.amountType",
      "short" : "An operator for the amount, for example \"average\", \"approximately\", \"less than\"",
      "definition" : "An operator for the amount, for example \"average\", \"approximately\", \"less than\".",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.relationship.source",
      "path" : "SubstanceSpecification.relationship.source",
      "short" : "Supporting literature",
      "definition" : "Supporting literature.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/DocumentReference"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.nucleicAcid",
      "path" : "SubstanceSpecification.nucleicAcid",
      "short" : "Data items specific to nucleic acids",
      "definition" : "Data items specific to nucleic acids.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceNucleicAcid"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.polymer",
      "path" : "SubstanceSpecification.polymer",
      "short" : "Data items specific to polymers",
      "definition" : "Data items specific to polymers.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstancePolymer"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.protein",
      "path" : "SubstanceSpecification.protein",
      "short" : "Data items specific to proteins",
      "definition" : "Data items specific to proteins.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceProtein"]
      }],
      "isSummary" : true
    },
    {
      "id" : "SubstanceSpecification.sourceMaterial",
      "path" : "SubstanceSpecification.sourceMaterial",
      "short" : "Material or taxonomic/anatomical source for the substance",
      "definition" : "Material or taxonomic/anatomical source for the substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceSourceMaterial"]
      }],
      "isSummary" : true
    }]
  }
}

Примечание к использованию: мы очень стараемся приводить корректные и полезные примеры, но нормативно они не являются частью спецификации.